Liver iron sensing and body iron homeostasis
The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …
Iron homeostasis and organismal aging
Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …
red blood cell function and many essential proteins and enzymes required for numerous …
Control of iron deficiency anemia in low-and middle-income countries
SR Pasricha, H Drakesmith, J Black… - Blood, The Journal …, 2013 - ashpublications.org
Despite worldwide economic and scientific development, more than a quarter of the world's
population remains anemic, and about half of this burden is a result of iron deficiency …
population remains anemic, and about half of this burden is a result of iron deficiency …
Hepcidin and iron regulation, 10 years later
T Ganz - Blood, The Journal of the American Society of …, 2011 - ashpublications.org
Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron
supply for hemoglobin synthesis and essential metabolic functions, humans and other …
supply for hemoglobin synthesis and essential metabolic functions, humans and other …
Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos
MP Conomos, CA Laurie, AM Stilp, SM Gogarten… - The American Journal of …, 2016 - cell.com
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …
exposures. Here, we characterized and controlled for this diversity in genome-wide …
Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
CM Beall, GL Cavalleri, L Deng… - Proceedings of the …, 2010 - National Acad Sciences
By impairing both function and survival, the severe reduction in oxygen availability
associated with high-altitude environments is likely to act as an agent of natural selection …
associated with high-altitude environments is likely to act as an agent of natural selection …
Regulation of iron transport and the role of transferrin
K Gkouvatsos, G Papanikolaou… - Biochimica et Biophysica …, 2012 - Elsevier
BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …
processes. However, iron may also harm cells by catalyzing the generation of free radicals …
Physiology of iron metabolism
S Waldvogel-Abramowski, G Waeber… - Transfusion Medicine …, 2014 - karger.com
A revolution occurred during the last decade in the comprehension of the physiology as well
as in the physiopathology of iron metabolism. The purpose of this review is to summarize the …
as in the physiopathology of iron metabolism. The purpose of this review is to summarize the …
Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment
A Pietrangelo - Gastroenterology, 2010 - Elsevier
In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Variation in body iron is associated with or causes diseases, including anaemia and iron
overload. Here, we analyse genetic association data on biochemical markers of iron status …
overload. Here, we analyse genetic association data on biochemical markers of iron status …