The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Despite worldwide economic and scientific development, more than a quarter of the world's
population remains anemic, and about half of this burden is a result of iron deficiency …

Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron
supply for hemoglobin synthesis and essential metabolic functions, humans and other …

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

By impairing both function and survival, the severe reduction in oxygen availability
associated with high-altitude environments is likely to act as an agent of natural selection …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …

A revolution occurred during the last decade in the comprehension of the physiology as well
as in the physiopathology of iron metabolism. The purpose of this review is to summarize the …

In the late 1800s, hemochromatosis was considered an odd autoptic finding. More than a
century later, it was finally recognized as a hereditary, multi-organ disorder associated with a …

Variation in body iron is associated with or causes diseases, including anaemia and iron
overload. Here, we analyse genetic association data on biochemical markers of iron status …