Proline analogues are versatile chemical building blocks that enable modular construction
of small-molecule drugs and pharmaceutical peptides. Over the past 15 years, the FDA has …

The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP
IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been …

The influence of a bulky 5-position substituent on the amide isomer equilibrium N-terminal to
proline has been explored via the synthesis and analysis of N-(acetyl) proline N ' …

A practical synthesis of 2, 4-methanopyrrolidines was elaborated. The key synthetic step
was an intramolecular photochemical [2+ 2]-cycloaddition of an acrylic acid derivative in …

Attention is focused on l-5, 5-dimethylproline (dmP) as a substitute to lock l-proline (Pro) in a
cis conformation in peptides and proteins, to prevent cis/trans isomerization when a protein …

We have proposed that development of methods for controlling theside-chain topography of
amino acid residues in peptides and proteins provides a new approach to the topographical …

Among the proteinogenic amino acids, only proline is a secondary amine and only proline
has a saturated ring. Electronegative substituents on C-4 (that is, Cγ) have a substantial …

The first fluorinated analogue of the naturally occurring 2, 4-methanoproline, 4-fluoro-2, 4-
methanoproline, has been synthesized in five steps from commercially available methyl 2 …

For many years, bovine pancreatic ribonuclease A (RNase A, EC 3.1. 27.5) has been a
model protein for studies of protein structure, energetics, disulfide-bond reactions, and …

Total synthesis of cyclobutane amino acids from Atelia herbert smithii Page 1 J. Org. Chem.
53,4793-4796 4793 408 (5), 391 (59), 349 (56), 348 (54), 307 (34), 306 (30), 289 (57), 247 (39) …