DNA methylation plays an important role in gene expression, chromatin stability, and genetic
imprinting. In mammals, DNA methylation patterns are written and regulated by DNA …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …

Colorectal cancer is a complex disease resulting from somatic genetic and epigenetic
alterations, including locus-specific CpG island methylation and global DNA or LINE-1 …

Colorectal cancer (CRC) develops through a multistage process that results from the
progressive accumulation of genetic mutations, and frequently as a result of mutations in the …

Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic
response; however, exact molecular mechanisms remain unclear. Recently, alongside the …

Most colorectal cancers (CRCs) containing activated BRAF (BRAF [V600E]) have a CpG
island methylator phenotype (CIMP) characterized by aberrant hypermethylation of many …

Recent evidence highlights the potential prognostic and predictive value of BRAF and K‐
RAS gene alterations in patients with colorectal cancer. However, a comprehensive …

Loss-of-function defects in DNA mismatch repair (MMR), which manifest as high levels of
microsatellite instability (MSI), occur in approximately 15% of all colorectal carcinomas …