Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …

The latest years have witnessed a growing interest towards the relationship between
neuropsychiatric disease in children with autism spectrum disorders (ASD) and severe …

Transactivating response region DNA binding protein 43 (TDP-43) pathology is prevalent in
dementia, but the cell type–specific effects of TDP-43 pathology are not clear, and …

Neuronal presynaptic terminals contain hundreds of neurotransmitter‐filled synaptic vesicles
(SVs). The morphologically uniform SVs differ in their release competence segregating into …

Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene,
encoding G protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2), have …

At CA1→ subiculum synapses, alternatively spliced neurexin-1 (Nrxn1 SS4+) and neurexin-
3 (Nrxn3 SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively …

Background Long-term alcohol exposure is associated with oxidative stress, endoplasmic
reticulum (ER) stress, and neuroinflammation, which may impair cognitive function …

While our understanding of the nanoscale architecture of anterograde synaptic transmission
is rapidly expanding, the qualitative and quantitative molecular principles underlying distinct …

There has been a significant increase in the consumption of cannabis for both recreational
and medicinal purposes in recent years, and its use can have long-term consequences on …

Long-term synaptic plasticity is critical for adaptive function of the brain, but presynaptic
mechanisms of functional plasticity remain poorly understood. Here, we show that changes …