Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Liquid biopsy methodologies, for the purpose of plasma genotyping of cell-free DNA (cfDNA)
of solid tumors, are a new class of novel molecular assays. Such assays are rapidly entering …

Patient-derived tumor xenograft (PDX) mouse models have emerged as an important
oncology research platform to study tumor evolution, mechanisms of drug response and …

Animal‐based research and drug safety studies are essential to understanding the
mysteries of nature and the long‐term survival of humans. Due to the rapid increase in the …

Patient-derived xenograft (PDX) models have recently emerged as a highly desirable
platform in oncology and are expected to substantially broaden the way in vivo studies are …

The lack of genetically diverse preclinical animal models in basic biology and efficacy
testing has been cited as a potential cause of failure in clinical trials. We developed and …

Colorectal cancer (CRC) is a challenging disease, with a high mortality rate and limited
effective treatment options, particularly for late-stage disease. Patient-derived xenografts …

Cell line‐derived xenograft (CDX) models created by implanting cancer cell lines into
immunodeficient mice have contributed largely to the development of cancer drug therapies …

Pancreatic cancer remains among the most lethal cancers worldwide, with poor early
detection rates and poor survival rates. Patient-derived xenograft (PDX) models have …

Background Patients-derived xenograft (PDX) model have been widely used for tumor
biological and pathological studies. However, the metabolic similarity of PDX tumor to the …