Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

The aryl hydrocarbon receptor (AhR) mediates various cellular responses upon exposure to
exogenous and endogenous stress factors. In these responses, AhR plays a dual role as a …

The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is
implicated in major depression. The human 5-HT1A gene (HTR1A) rs6295 risk allele …

Background Accurate regulation of tissue-and stage-specific expression of genes is
prerequisite for normal development in organisms. DNA methylation plays an important role …

Deformed epidermal autoregulatory factor‐1 (DEAF1), a transcription factor essential for
central nervous system and early embryonic development, has recently been implicated in a …

De novo deleterious and heritable biallelic mutations in the DNA binding domain (DBD) of
the transcription factor deformed epidermal autoregulatory factor 1 (DEAF1) result in a …

NF-Y is a trimeric Transcription Factor-TF-which binds with high selectivity to the conserved
CCAAT element. Individual ChIP-seq analysis as well as ENCODE have progressively …

Innate immunity is crucial for invertebrate defense against pathogenic infections. Numerous
studies have indicated that the Toll–NF–κB pathway plays an important role in this process …

After the first reported case of Zika virus (ZIKV) in Brazil, in 2015, a significant increase in the
reported cases of microcephaly was observed. Microcephaly is a neurological condition in …

Abstract RAI1 (retinoic acid induced-1) is a dosage-sensitive gene that causes Smith-
Magenis syndrome (SMS) when mutated or deleted and Potocki-Lupski Syndrome (PTLS) …