A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder
SS Purushotham, NMN Reddy, MN D'Souza… - Experimental Brain …, 2022 - Springer
Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2 …
disorders that have become a primary clinical and social concern, with a prevalence of 2 …
A comprehensive review of the PTEN/PI3K/Akt axis in multiple myeloma: from molecular interactions to potential therapeutic targets
Phosphatase and tensin homolog (PTEN), phosphatidylinositol 3-kinase (PI3K), and protein
kinase B (Akt) signaling pathways contribute to the development of several cancers …
kinase B (Akt) signaling pathways contribute to the development of several cancers …
Multipotent progenitors instruct ontogeny of the superior colliculus
The superior colliculus (SC) in the mammalian midbrain is essential for multisensory
integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia …
integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia …
The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of daf-18/PTEN Caenorhabditis elegans mutants
S Giunti, MG Blanco, MJ De Rosa, D Rayes - Elife, 2024 - elifesciences.org
A finely tuned balance between excitation and inhibition (E/I) is essential for proper brain
function. Disruptions in the GABAergic system, which alter this equilibrium, are a common …
function. Disruptions in the GABAergic system, which alter this equilibrium, are a common …
Dual impact of PTEN mutation on CSF dynamics and cortical networks via the dysregulation of neural precursors and their interneuron descendants
Expansion of the cerebrospinal fluid (CSF)-filled cerebral ventricles (ventriculomegaly) is the
quintessential feature of congenital hydrocephalus (CH) but also seen in autism spectrum …
quintessential feature of congenital hydrocephalus (CH) but also seen in autism spectrum …