[HTML][HTML] Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

[HTML][HTML] More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures

S Ruiz García, M Deprez, K Lebrigand… - …, 2019 - journals.biologists.com
The upper airway epithelium, which is mainly composed of multiciliated, goblet, club and
basal cells, ensures proper mucociliary function and can regenerate in response to assaults …

[HTML][HTML] NF-kappaB signaling in chronic inflammatory airway disease

M Schuliga - Biomolecules, 2015 - mdpi.com
Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders
which differ in their underlying causes and phenotypes but overlap in patterns of …

[HTML][HTML] The epithelium in idiopathic pulmonary fibrosis: breaking the barrier

A Camelo, R Dunmore, MA Sleeman… - Frontiers in …, 2014 - frontiersin.org
Idiopathic pulmonary fibrosis is a progressive disease of unknown etiology characterized by
a dysregulated wound healing response that leads to fatal accumulation of fibroblasts and …

[HTML][HTML] The airway epithelium—A central player in asthma pathogenesis

J Calvén, E Ax, M Rådinger - International Journal of Molecular Sciences, 2020 - mdpi.com
Asthma is a chronic inflammatory airway disease characterized by variable airflow
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …

[HTML][HTML] Equine asthma: current understanding and future directions

L Couetil, JM Cardwell, R Leguillette… - Frontiers in veterinary …, 2020 - frontiersin.org
The 2019 Havemeyer Workshop brought together researchers and clinicians to discuss the
latest information on Equine Asthma and provide future research directions. Current clinical …

Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease

YS Prakash - American Journal of Physiology-Lung Cellular …, 2016 - journals.physiology.org
Airway structure and function are key aspects of normal lung development, growth, and
aging, as well as of lung responses to the environment and the pathophysiology of important …

[HTML][HTML] Targeting cytokines as evolving treatment strategies in chronic inflammatory airway diseases

J Garth, JW Barnes, S Krick - International journal of molecular sciences, 2018 - mdpi.com
Cytokines are key players in the initiation and propagation of inflammation in chronic
inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD) …

[HTML][HTML] Altered generation of ciliated cells in chronic obstructive pulmonary disease

S Gohy, FM Carlier, C Fregimilicka, B Detry… - Scientific reports, 2019 - nature.com
In COPD, epithelial changes are prominent features in the airways, such as goblet cell
hyperplasia and squamous metaplasia. In contrast, it remains unclear whether ciliated cells …