Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential

C Ceci, PM Lacal, G Graziani - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …

Recent updates on the resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors and resistance reversion strategies in lung cancer

SK Tripathi, K Pandey… - Medicinal Research …, 2020 - Wiley Online Library
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have led to a
substantial improvement in the prognosis of lung cancer patients by explicitly targeting the …

Dual-receptor-targeted nanomedicines: emerging trends and advances in lung cancer therapeutics

Vikas, HK Sahu, AK Mehata, MK Viswanadh… - …, 2022 - Taylor & Francis
Cancer is the leading cause of mortality worldwide. Among all cancer types, lung cancer is
recognized as the most lethal and highly metastatic. The application of targeted …

The impact of inflammation and acute phase activation in cancer cachexia

TP Robinson, T Hamidi, B Counts… - Frontiers in …, 2023 - frontiersin.org
The development of cachexia in the setting of cancer or other chronic diseases is a
significant detriment for patients. Cachexia is associated with a decreased ability to tolerate …

Efficacy of the antibody–drug conjugate W0101 in preclinical models of IGF-1 receptor overexpressing solid tumors

B Akla, M Broussas, N Loukili, A Robert… - Molecular Cancer …, 2020 - AACR
The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis, and its
overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based …

Targeting the IGF-axis for cancer therapy: development and validation of an IGF-trap as a potential drug

YM Chen, S Qi, S Perrino, M Hashimoto, P Brodt - Cells, 2020 - mdpi.com
The insulin-like growth factor (IGF)-axis was implicated in cancer progression and identified
as a clinically important therapeutic target. Several IGF-I receptor (IGF-IR) targeting drugs …

Glycemic index, glycemic load, and lung cancer risk: A meta-analysis of cohort and case-control studies

H Du, T Zhang, X Lu, M Chen, X Li, Z Li - Plos one, 2022 - journals.plos.org
Objective Glycemic index (GI) or glycemic load (GL) has been investigated in the field of
cancer research for several years. However, the relationship between GI or GL and lung …

[HTML][HTML] The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer

AW Pohlman, H Moudgalya, L Jordano, GC Lobato… - Oncotarget, 2022 - ncbi.nlm.nih.gov
Background: Detection rates of early-stage lung cancer are traditionally low, which
contributes to inconsistent treatment responses and high rates of annual cancer deaths …

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

W Tang, S Chen, J Liu, C Liu, Y Wang… - Journal of cellular …, 2019 - Wiley Online Library
Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and
overweight. Thus, any variant in energy metabolism–related gene may influence the …

Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic …

M Hada, H Oh, RM Pfeiffer, RT Falk, S Fan… - breast cancer …, 2019 - Springer
Background Mammographic density (MD) is a strong breast cancer risk factor that reflects
fibroglandular and adipose tissue composition, but its biologic underpinnings are poorly …