Antibody-drug conjugates: Resurgent anticancer agents with multi-targeted therapeutic potential
C Ceci, PM Lacal, G Graziani - Pharmacology & Therapeutics, 2022 - Elsevier
Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …
whose first appearance took place about two decades ago, but a renewed interest occurred …
Recent updates on the resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors and resistance reversion strategies in lung cancer
SK Tripathi, K Pandey… - Medicinal Research …, 2020 - Wiley Online Library
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have led to a
substantial improvement in the prognosis of lung cancer patients by explicitly targeting the …
substantial improvement in the prognosis of lung cancer patients by explicitly targeting the …
Dual-receptor-targeted nanomedicines: emerging trends and advances in lung cancer therapeutics
Cancer is the leading cause of mortality worldwide. Among all cancer types, lung cancer is
recognized as the most lethal and highly metastatic. The application of targeted …
recognized as the most lethal and highly metastatic. The application of targeted …
The impact of inflammation and acute phase activation in cancer cachexia
TP Robinson, T Hamidi, B Counts… - Frontiers in …, 2023 - frontiersin.org
The development of cachexia in the setting of cancer or other chronic diseases is a
significant detriment for patients. Cachexia is associated with a decreased ability to tolerate …
significant detriment for patients. Cachexia is associated with a decreased ability to tolerate …
Efficacy of the antibody–drug conjugate W0101 in preclinical models of IGF-1 receptor overexpressing solid tumors
B Akla, M Broussas, N Loukili, A Robert… - Molecular Cancer …, 2020 - AACR
The insulin-like growth factor type 1 receptor (IGF-1R) is important in tumorigenesis, and its
overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based …
overexpression occurs in numerous tumor tissues. To date, therapeutic approaches based …
Targeting the IGF-axis for cancer therapy: development and validation of an IGF-trap as a potential drug
YM Chen, S Qi, S Perrino, M Hashimoto, P Brodt - Cells, 2020 - mdpi.com
The insulin-like growth factor (IGF)-axis was implicated in cancer progression and identified
as a clinically important therapeutic target. Several IGF-I receptor (IGF-IR) targeting drugs …
as a clinically important therapeutic target. Several IGF-I receptor (IGF-IR) targeting drugs …
Glycemic index, glycemic load, and lung cancer risk: A meta-analysis of cohort and case-control studies
H Du, T Zhang, X Lu, M Chen, X Li, Z Li - Plos one, 2022 - journals.plos.org
Objective Glycemic index (GI) or glycemic load (GL) has been investigated in the field of
cancer research for several years. However, the relationship between GI or GL and lung …
cancer research for several years. However, the relationship between GI or GL and lung …
[HTML][HTML] The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer
AW Pohlman, H Moudgalya, L Jordano, GC Lobato… - Oncotarget, 2022 - ncbi.nlm.nih.gov
Background: Detection rates of early-stage lung cancer are traditionally low, which
contributes to inconsistent treatment responses and high rates of annual cancer deaths …
contributes to inconsistent treatment responses and high rates of annual cancer deaths …
Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk
W Tang, S Chen, J Liu, C Liu, Y Wang… - Journal of cellular …, 2019 - Wiley Online Library
Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and
overweight. Thus, any variant in energy metabolism–related gene may influence the …
overweight. Thus, any variant in energy metabolism–related gene may influence the …
Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic …
M Hada, H Oh, RM Pfeiffer, RT Falk, S Fan… - breast cancer …, 2019 - Springer
Background Mammographic density (MD) is a strong breast cancer risk factor that reflects
fibroglandular and adipose tissue composition, but its biologic underpinnings are poorly …
fibroglandular and adipose tissue composition, but its biologic underpinnings are poorly …