Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …

Toll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells
and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in …

Toll-like receptors (TLR) s are homo-or heterodimeric proteins, whose structure and function
were widely described in the antigen presenting cells (APC), such as Dendritic cells (DC) …

Abstract Toll-like receptors (TLRs), found on antigen-presenting cells including
macrophages and dendritic cells, are essential for identifying infections and initiating …

Systemic drug delivery is the current clinically preferred route for cancer therapy. However,
challenges associated with tumor localization and off-tumor toxic effects limit the clinical …

As a currently spotlighted method for cancer treatment, cancer immunotherapy has made a
lot of progress in recent years. Among tremendous cancer immunotherapy boosters …

Viral infections are usually accompanied by systemic cytokinemia. Vaccines need not
necessarily mimic infection by inducing cytokinemia, but must induce antiviral-acquired …

Nanomedicine offers considerable opportunities to improve drugability and reduce toxicity
for tumour therapy. However, the application of nanomedicine has achieved little success in …

Background Radiofrequency ablation (RFA) destroys tumors through hyperthermic injury,
which induces the release of immunogenic intracellular substrates and damages associated …

Simple Summary The clinical use of immunoadjuvants is limited by transient responses and
various side effects. This study investigated the multi-adjuvant approach of combining a TLR …