Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in
the research of tumor progression. Treg cells have the function of inhibiting the immune …

Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment.
Despite demonstrable progress, most patients fail to respond or achieve durable responses …

The genetic circuits that allow cancer cells to evade immune killing via epithelial
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like …

Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains …

Genetic information that is transcribed from DNA to mRNA, and then translated from mRNA
to protein, is regulated by complex and sophisticated post-transcriptional mechanisms …

Autoantibody-mediated glomerulonephritis (AGN) arises from dysregulated renal
inflammation, with urgent need for improved treatments. IL-17 is implicated in AGN and …

AT-rich interactive domain 5a (Arid5a) is a nucleic acid binding protein. In this review, we
highlight recent advances in the association of Arid5a with inflammation and human …

Cancer cells undergo phenotypic switching (cancer cell plasticity) in response to
microenvironmental cues, including exposure to therapy/treatment. Phenotypic plasticity …

Background A minute fraction of patients stands to derive substantial benefits from
immunotherapy, primarily attributable to immune evasion. Our objective was to formulate a …

Resistance to chimeric antigen receptor (CAR) T-cell therapy remains a significant
challenge in the treatment of solid tumors. This resistance is attributed to various factors …