Are novel, nonrandomized analytic methods fit for decision making? The need for prospective, controlled, and transparent validation

HG Eichler, F Koenig, P Arlett… - Clinical …, 2020 - Wiley Online Library
Real‐world data and patient‐level data from completed randomized controlled trials are
becoming available for secondary analysis on an unprecedented scale. A range of novel …

Clinical Pharmacology Applications of Real‐World Data and Real‐World Evidence in Drug Development and Approval–An Industry Perspective

R Zhu, B Vora, S Menon, I Younis… - Clinical …, 2023 - Wiley Online Library
Since the 21st Century Cures Act was signed into law in 2016, real‐world data (RWD) and
real‐world evidence (RWE) have attracted great interest from the healthcare ecosystem …

Validity of chronic venous disease diagnoses and epidemiology using validated electronic health records from primary care: A real‐world data Analysis

E Homs‐Romero, A Romero‐Collado… - Journal of Nursing …, 2021 - Wiley Online Library
Purpose The aim of this study was to evaluate the validity of lower limb chronic venous
disease (CVD) diagnoses entered in a large electronic health record database in primary …

Artificial neural network vs. pharmacometric model for population prediction of plasma concentration in real‐world data: a case study on valproic acid

H Soeorg, E Sverrisdóttir, M Andersen… - Clinical …, 2022 - Wiley Online Library
We compared the predictive performance of an artificial neural network to traditional
pharmacometric modeling for population prediction of plasma concentrations of valproate in …

The present and future scope of real‐world evidence research in diabetes: what questions can and cannot be answered and what might be possible in the future?

F Zaccardi, MJ Davies, K Khunti - Diabetes, Obesity and …, 2020 - Wiley Online Library
The last decade has witnessed an exponential growth in the opportunities to collect and link
health‐related data from multiple resources, including primary care, administrative, and …

Real‐World Evidence Application in Translational Medicine: Making Use of Prescription Claims to Inform Drug–Drug Interactions of a New Psoriasis Treatment

CKC Choong, J Rehmel… - The Journal of Clinical …, 2024 - Wiley Online Library
Patients with psoriasis often take multiple medications due to comorbidities, raising
concerns about drug–drug interactions (DDIs) during the development of new medicines …

[PDF][PDF] COVID-19 и клиническая фармакология

АС Колбин - Клиническая фармакология и терапия, 2020 - clinpharm-journal.ru
В статье рассматривается роль клинической фармакологии в управлении пандемией
COVID-19, в частности разработке лекарственных средств, оказывающих действие на …

[HTML][HTML] Данные рутинной практики (real-world data): от планирования к анализу

АГ Солодовников, ЕЮ Сорокина… - … технологии. Оценка и …, 2020 - cyberleninka.ru
В последние несколько лет в России значительно вырос интерес фармацевтической
отрасли и медицинского сообщества к направлению real-world evidence (RWE …

Evidenzbasierte Arzneimittelversorgung bei Seltenen Erkrankungen: die Rolle der Digitalisierung

F Naumann-Winter, T Kaiser, A Behring - Bundesgesundheitsblatt …, 2022 - Springer
Zusammenfassung Bei der Wissensgenerierung im Bereich der Arzneimittelentwicklung für
Menschen mit Seltenen Erkrankungen (SE) sind besondere Schwierigkeiten zu überwinden …

A novel method for continuous measurements of clinical practice guideline adherence

KCWJ Ebben, CD de Kroon… - Learning Health …, 2023 - Wiley Online Library
Introduction Clinical practice guidelines (hereafter 'guidelines') are crucial in providing
evidence‐based recommendations for physicians and multidisciplinary teams to make …