Tumor-associated macrophages (TAMs) are important tumor-promoting cells in the breast
tumor microenvironment. Preclinically TAMs stimulate breast tumor progression, including …

Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis.
Hence, AA pathway metabolic enzymes phospholipase A 2 s (PLA 2 s), cyclooxygenases …

The activation of nuclear factor-kappaB (NFΚB), a proinflammatory transcription factor, is a
commonly observed phenomenon in breast cancer. It facilitates the development of a …

Breast cancer is the most common in women worldwide, with some 5-10% of all cases due
to inherited mutations of BRCA1 and BRCA2 genes. Obesity, hormone therapy and use of …

Background and Objectives: It is generally accepted that inflammatory cells found in the
tumor microenvironment are involved in the neoplastic process, promoting cell proliferation …

Typically, tumor‑associated macrophages (TAMs), an abundant population of leukocytes in
lung cancer, are affected by tumor microenvironment (TME) and shift towards either a pro …

Background Breast cancer is still the most common malignant tumor that threatens the
female's life in the world, especially triple-negative breast cancer (TNBC), one of the most …

Background Triple-negative breast cancers represent an important clinical challenge, as
these cancers do not respond to conventional endocrine therapies or other available …

Drug repurposing is a valuable approach in delivering new cancer therapeutics rapidly into
the clinic. Existing safety and patient tolerability data for drugs already in clinical use …

Background High breast density is linked to an increased risk of breast cancer, and
correlates with changes in collagen. In a mouse model of mammary carcinoma in the context …