The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Astrocytes are the most abundant cell type in the brain. They were long considered only as
passive support for neuronal cells. However, recent data have revealed many active roles …

Background Microglia are the endogenous immune cells of the brain and act as sensors of
pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer's …

Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …

In Parkinsons disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra
pars compacta is associated with Lewy bodies arising from the accumulation of alpha …

Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds,
APOE4, PSEN1ΔE9, and APPswe, on functionality of human microglia-like cells (iMGLs) …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …

Background: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
have emerged as a promising experimental tool for translational heart research and drug …

Abstract LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated
mutations and has been shown to alter microglial functionality. However, the impact of …

Limited evidence has shed light on how aSYN proteins affect the oligodendrocyte
phenotype and pathogenesis in synucleinopathies that include Parkinson's disease (PD) …