The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace

I Roca, P Espinal, X Vila-Farrés, J Vila - Frontiers in microbiology, 2012 - frontiersin.org
During the past few decades Acinetobacter baumannii has evolved from being a commensal
dweller of health-care facilities to constitute one of the most annoying pathogens …

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

PC Sharma, A Jain, S Jain, R Pahwa… - Journal of enzyme …, 2010 - Taylor & Francis
In the current practices of antiinfective therapy, ciprofloxacin is a very popular
fluoroquinolone having a broad spectrum of activity and diverse therapeutic prospects. The …

Recent developments of quinolone-based derivatives and their activities against Escherichia coli

F Gao, P Wang, H Yang, Q Miao, L Ma, G Lu - European Journal of …, 2018 - Elsevier
Escherichia coli (E. coli) is the most common pathogen in both hospital and community
settings, and is capable of causing infections that can lead to serious consequences …

Therapeutic options for Acinetobacter baumannii infections: an update

J Vila, J Pachon - Expert opinion on pharmacotherapy, 2012 - Taylor & Francis
Introduction: Although the clinical importance of Acinetobacter pittii and Acinetobacter
nosocomialis has increased in the nosocomial setting in the last decade, infections caused …

N4-substituted piperazinyl norfloxacin derivatives with broad-spectrum activity and multiple mechanisms on gyrase, topoisomerase IV, and bacterial cell wall synthesis

AM Kamal El-sagheir… - ACS bio & med …, 2023 - ACS Publications
Fluoroquinolones are an important class of antibiotics with broad-spectrum antibacterial and
antitubercular activity. Here, we describe the design and synthesis of a series of 38 N 4 …

Conjugation of ciprofloxacin with poly (2-oxazoline) s and polyethylene glycol via end groups

M Schmidt, S Harmuth, ER Barth, E Wurm… - Bioconjugate …, 2015 - ACS Publications
The antibiotic ciprofloxacin (CIP) was covalently attached to the chain end of poly (2-
methyloxazoline)(PMOx), poly (2-ethyloxazoline)(PEtOx), and polyethylene glycol (PEG) …

Recent advancements and perspective of ciprofloxacin-based antimicrobial polymers

S Kanth, Y Malgar Puttaiahgowda… - Journal of Biomaterials …, 2023 - Taylor & Francis
In recent years, microbial pathogens, which are major sources of infections, have become a
widespread concern across the world. The number of deaths caused by infectious diseases …

Medicinal potential of ciprofloxacin and its derivatives

W Castro, M Navarro, C Biot - Future medicinal chemistry, 2013 - Taylor & Francis
Ciprofloxacin (CP) is a fluoroquinolone that is highly active against diverse microorganisms.
At concentrations less than 1 µg/ml it is active against a diverse types of bacteria, including …

Spray dried inhalable ciprofloxacin powder with improved aerosolisation and antimicrobial activity

R Osman, PL Kan, G Awad, N Mortada… - International journal of …, 2013 - Elsevier
In this study, the spray drying technique was used to prepare ciprofloxacin microparticles
(CFX-MPs) for pulmonary administration. By virtue of its amphoteric properties, CFX was …

Conjugates of ciprofloxacin and amphiphilic block copoly (2-alkyl-2-oxazolines) s overcome efflux pumps and are active against CIP-resistant bacteria

A Romanovska, J Keil, J Tophoven… - Molecular …, 2021 - ACS Publications
Conjugation of antibiotics with polymers is an emerging strategy to improve the performance
of these important drugs. Here, the antibiotic ciprofloxacin (CIP) was conjugated with …