Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand gated ion
channels which are widely distributed in the human brain. Multiple subtypes of these …

Nicotine has been shown to have effects on anxiety and depression in both human and
animal studies. These studies suggest that nicotinic acetylcholine receptors (nAChRs) can …

Coffee is a widely consumed beverage containing numerous biologically active constituents
predominantly belonging to the polyphenol and alkaloid classes. It has been established …

While the monoamine deficiency hypothesis of depression is still most commonly used to
explain the actions of antidepressant drugs, a growing body of evidence has accumulated …

Individuals with attentional and emotional dysfunctions are most at risk for smoking initiation
and subsequent nicotine addiction. This article presents converging findings from human …

Nicotinic acetylcholine receptors (nAChRs) are diverse members of the neurotransmitter‐
gated ion channel superfamily and play critical roles in chemical signaling throughout the …

Background: Desipramine a representative of tricyclic antidepressants (TCAs) promotes
recovery of depressed patients by inhibition of reuptake of neurotransmitters serotonin …

Current literature suggests involvement of nicotinic acetylcholine receptors (nAChRs) in
major depression. However, it is controversial whether the antidepressant-like effect of …

Antidepressants inhibit many membrane receptors and ionic channels, including the L-type
calcium channel. Here, we investigated the inhibition of calcium current (I Ca) by …

The high rates of co-morbidity of drug addiction with depression may be attributable to
shared neurobiology. Here, we discuss shared neurobiological substrates in drug …