[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

[HTML][HTML] Understanding acquired brain injury: a review

L Goldman, EM Siddiqui, A Khan, S Jahan… - Biomedicines, 2022 - mdpi.com
Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI).
In general, ABI does not result from congenital disorders, degenerative diseases, or by brain …

Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention

A Kumar, DJ Loane - Brain, behavior, and immunity, 2012 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide, yet despite extensive efforts to develop neuroprotective therapies for this …

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

D Shlosberg, M Benifla, D Kaufer… - Nature Reviews …, 2010 - nature.com
Traumatic brain injury (TBI) is the leading cause of death in young adults and children. The
treatment of TBI in the acute phase has improved substantially; however, the prevention and …

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

DJ Loane, AI Faden - Trends in pharmacological sciences, 2010 - cell.com
Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …

Astrogliosis in CNS pathologies: is there a role for microglia?

D Zhang, X Hu, L Qian, JP O'Callaghan… - Molecular neurobiology, 2010 - Springer
Astrogliosis, a cellular reaction with specific structural and functional characteristics,
represents a remarkably homotypic response of astrocytes to all kinds of central nervous …

Cell death mechanisms and modulation in traumatic brain injury

BA Stoica, AI Faden - Neurotherapeutics, 2010 - Springer
Cell death after traumatic brain injury (TBI) is a major cause of neurological deficits and
mortality. Understanding the mechanisms of delayed post-traumatic cell loss may lead to …

[HTML][HTML] Neuroprotective strategies for traumatic brain injury: improving clinical translation

SV Kabadi, AI Faden - International journal of molecular sciences, 2014 - mdpi.com
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …

[HTML][HTML] Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled …

SA Acosta, N Tajiri, K Shinozuka, H Ishikawa… - PloS one, 2013 - journals.plos.org
The long-term consequences of traumatic brain injury (TBI), specifically the detrimental
effects of inflammation on the neurogenic niches, are not very well understood. In the …

Neurological effects of blast injury

RR Hicks, SJ Fertig, RE Desrocher… - Journal of Trauma …, 2010 - journals.lww.com
Over the last few years, thousands of soldiers and an even greater number of civilians have
suffered traumatic injuries due to blast exposure, largely attributed to improvised explosive …