The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family
of receptors that often undergo autoproteolysis to produce α and β subunits,–. A tethered …

The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful blood-
borne factors. Although BBB dysfunction is a hallmark of several neurological disorders …

Adhesion G-protein-coupled receptors (aGPCRs) are important for organogenesis,
neurodevelopment, reproduction and other processes,,,,–. Many aGPCRs are activated by a …

During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

Adhesion G-protein-coupled receptors (GPCRs) are a major family of GPCRs, but limited
knowledge of their ligand regulation or structure is available,–. Here we report that …

Activation of hepatic stellate cells (HSCs) represents the primary driving force to promote the
progression of chronic cholestatic liver diseases. We previously reported that cholangiocyte …