Spondyloarthritis (SpA) encompasses a heterogeneous group of chronic inflammatory
diseases that can affect both axial and peripheral joints, tendons and entheses. Among the …

Autoimmune and autoinflammatory conditions represent a group of disorders characterized
by self-directed tissue damage due to aberrant changes in innate and adaptive immune …

The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in
shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I …

The term spondyloarthritis (SpA) encompasses a group of chronic inflammatory diseases
with common features in terms of clinical presentation and genetic predisposition. SpA is …

Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong
association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the …

Abstract The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated
in a variety of immune and non-immune functions. Most studies however have focused on …

Background The human leucocyte antigen (HLA) complex, located at chromosome 6p21. 3
is a highly polymorphic region containing the classical class I and II HLA genes. The region …

Spondyloarthritis is a common type of arthritis which affects mostly adults. It consists of
idiopathic chronic inflammation of the spine, joints, eyes, skin, gut and prostate. Inflammation …

Autoimmune and autoinflammatory diseases affect millions worldwide. These classes of
disease involve abnormal immune activation of both the innate and adaptive immune …

Crohn's disease (CD) is regarded as a lifelong progressive disease affecting all segments of
the intestinal tract and multiple organs. Based on genome-wide association studies (GWAS) …