Small molecules as antibacterial agents have contributed immensely to the growth of
modern medicine over the last several decades. However, the emergence of drug resistance …

The human pulmonary environment is complex, containing a matrix of cells, including
fibroblasts, epithelial cells, interstitial macrophages, alveolar macrophages and neutrophils …

The BipA protein is a universally conserved GTPase in bacterial species and is structurally
similar to translational GTPases. Despite its wide distribution, BipA is dispensable for growth …

Severe and late-stage pneumonias are often difficult to treat with antibiotics alone due to
overwhelming host inflammatory responses mounted to clear infection. These host …

鼠疫(plague) 是由鼠疫耶尔森氏菌(Yersinia pesits) 引起的烈性传染病, 在人类历史上曾造成约
2 亿人的死亡, 在我国被列为甲类传染病. 由于鼠疫菌具有高度致病性, 传染性 …

Yersinia pestis is a lethal pathogen and the causative agent of plague. Pneumonic plague
results in 100% mortality within seven days without antibiotic intervention and is caused by …