Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023 - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

MR biomarkers of degenerative brain disorders derived from diffusion imaging

C Andica, K Kamagata, T Hatano… - Journal of Magnetic …, 2020 - Wiley Online Library
The incidence of neurodegenerative diseases has shown an increasing trend. These
conditions typically cause progressive functional disability. Identification of robust …

Biomarkers in motor neuron disease: a state of the art review

NS Verber, SR Shepheard, M Sassani… - Frontiers in …, 2019 - frontiersin.org
Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

[HTML][HTML] Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology

MD Tisdall, DT Ohm, R Lobrovich, SR Das, G Mizsei… - NeuroImage: Clinical, 2022 - Elsevier
Frontotemporal lobar degeneration (FTLD) is a heterogeneous spectrum of age-associated
neurodegenerative diseases that include two main pathologic categories of tau (FTLD-Tau) …

[HTML][HTML] Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis

C Wang, S Foxley, O Ansorge… - Neuroimage, 2020 - Elsevier
Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local
concentration of iron and myelin. Here, we describe a robust image processing pipeline for …

The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review

G Grolez, C Moreau, V Danel-Brunaud, C Delmaire… - BMC neurology, 2016 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a fatal, rapidly progressive
neurodegenerative disease that mainly affects the motor system. A number of potentially …

Neutrophil-mediated mechanisms of damage and in-vitro protective effect of colchicine in non-vascular Behçet's syndrome

A Bettiol, M Becatti, E Silvestri… - Clinical & …, 2021 - academic.oup.com
Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field …

M Pallebage-Gamarallage, S Foxley, RAL Menke… - BMC neuroscience, 2018 - Springer
Background Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically
heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid …

[HTML][HTML] Longitudinal evaluation of cerebral and spinal cord damage in amyotrophic lateral sclerosis

M de Albuquerque, LMT Branco, TJR Rezende… - Neuroimage: Clinical, 2017 - Elsevier
Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

Joint system relaxometry (JSR) and Crámer‐Rao lower bound optimization of sequence parameters: A framework for enhanced precision of DESPOT T1 and T2 …

RPAG Teixeira, SJ Malik… - Magnetic resonance in …, 2018 - Wiley Online Library
Purpose This study aims to increase the precision of single‐compartment DESPOT
relaxometry by two means:(i) a joint system relaxometry (JSR) approach that estimates …