Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in
various physiological as well as pathological processes. Over past decades, NO has …

Glutamate excitotoxicity is a hypothesis that states excessive glutamate causes neuronal
dysfunction and degeneration. As glutamate is a major excitatory neurotransmitter in the …

The metalloenzymes that have been named superoxide dismutases have several attributes.
They are abundant, widely distributed, essential as a defense against oxygen toxicity; they …

Nitric oxide contrasts with most intercellular messengers because it diffuses rapidly and
isotropically through most tissues with little reaction but cannot be transported through the …

We summarize here results of studies designed to elucidate basic mechanisms of reactive
oxygen (ROS)-mediated oxidation of proteins and free amino acids. These studies have …

There has been confusion as to what role (s) nitric oxide (NO) has in different physiological
and pathophysiological mechanisms. Some studies imply that NO has cytotoxic properties …

Free radicals and other oxygen-derived species are constantly generated in vivo, both by
“accidents of chemistry” and for specific metabolic purposes. The reactivity of different free …

The occurrence of protein tyrosine nitration under disease conditions is now firmly
established and represents a shift from the signal transducing physiological actions of• NO …

It has long been known that the photolysis of nitrite and nitrate solutions results in the
formation of OH radicals. The mechanism of NO3− photolysis has been the subject of …