Biospecimens acquired during routine medical practice are the primary sources of molecular
information about patients and their diseases that underlies precision medicine and …

The past decades have seen tremendous developments with respect to “specific”
therapeutics that target key signaling molecules to conquer cancer. The key advancements …

Identifying a suitable course of immunotherapy treatment for a given patient as well as
monitoring treatment response is heavily reliant on biomarkers detected and quantified in …

Abstract The National Cancer Institute conducted the Biospecimen Pre-analytical Variables
(BPV) study to determine the effects of formalin fixation and delay to fixation (DTF) on the …

Although cryopreservation of bull semen is widely used commercially in the livestock
breeding industry, cryopreservation results in low fertility of bull sperm. As an important …

Frequently investigators request that tissues be collected and processed in less than one
hour following removal from a patient. Some biorepositories expend significant personnel …

When dealing with pre-analytics for tissues, it is often that case that tissue heterogeneity,
and particularly tumor heterogeneity, is not taken into account as a preliminary condition for …

Background Gene expression is widely used for the characterisation of breast cancers.
Variability due to tissue heterogeneity or measurement error or systematic change due to …

One of the major challenges in biomarker development is the collection of tumor tissue of
adequate quality for analysis. A prospective clinical trial was initiated to collect tissues from …

The purpose of the present work is to underline the importance of obtaining a standardized
procedure to ensure and evaluate both clinical and research usability of human tissue …