Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Introduction Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder with an
incidence of 1 in 14–17,000 male births, caused by pathogenic variants within the ABCD1 …

Pathogenic variants in the ABCD1 gene cause adrenoleukodystrophy (ALD), a progressive
metabolic disorder characterized by 3 core clinical syndromes: a slowly progressive …

Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty
acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source …

Males with X‐linked adrenoleukodystrophy (ALD) are at high risk for developing adrenal
insufficiency and/or progressive leukodystrophy (cerebral ALD) at an early age. Pathogenic …

X-linked adrenoleukodystrophy (X-ALD) affects the nervous system white matter and the
adrenal cortex. Three main phenotypes are seen in affected males: The childhood cerebral …

X-linked adrenoleukodystrophy (ALD) is an inherited progressive neurometabolic disease
caused by mutations in the ABCD1 gene and the accumulation of very long-chain fatty acids …

X-linked adrenoleukodystrophy (ALD) is a progressive neurodegenerative disease caused
by mutations in ABCD1, the peroxisomal very long–chain fatty acid (VLCFA) transporter …

The advancements in population screening, including newborn screening, enables the
identification of disease-causing variants and timely initiation of treatment. However …

Peroxisomes are multifunctional organelles, well known for their role in cellular lipid
homeostasis. Their importance is highlighted by the life-threatening diseases caused by …