Alzheimer's disease (AD) was used to describe pre-senile dementia to differentiate it from
senile dementia, which develops in the adult age group of more than 65 years. AD is …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form
new memories. For many years, this dementia was attributed to nerve-cell death induced by …

Lipid rafts are membrane microdomains intimately associated with cell signaling. These
biochemical microstructures are characterized by their high contents of sphingolipids …

Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and
anti-oxidant effects. These are thought to be responsible for the potential effects of statins on …

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia and
affects up to 15 million people worldwide. Although no single cause of AD has been …

Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on
human health ranging from fatigue and numbness to organ failure and death in extreme …

The 39–42 amino acid long, amphipathic amyloid-β peptide (Aβ) is one of the key
components involved in Alzheimer's disease (AD). In the neuropathology of AD, Aβ …

Objective: To examine the association of plasma cholesterol levels, lipid-lowering agent
(LLA) intake, and APOE genotype with dementia prevalence. Methods: The Three-City Study …

Converging evidence from clinical and pathological studies indicate the presence of
important relationships between the ongoing deterioration of brain lipid homeostasis …