Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Y Shi, Y Wang, Q Li, K Liu, J Hou, C Shao… - Nature Reviews …, 2018 - nature.com
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …

Paracrine mechanisms of mesenchymal stem cells in tissue repair

M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

W Nassar, M El-Ansary, D Sabry, MA Mostafa… - Biomaterials …, 2016 - spj.science.org
Background Bio-products from stem/progenitor cells, such as extracellular vesicles, are
likely a new promising approach for reprogramming resident cells in both acute and chronic …

Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion

E Eggenhofer, V Benseler, A Kroemer… - Frontiers in …, 2012 - frontiersin.org
Mesenchymal stem cells (MSC) are under investigation as a therapy for a variety of
disorders. Although animal models show long term regenerative and immunomodulatory …

Mesenchymal stem cells deliver exogenous microRNA-let7c via exosomes to attenuate renal fibrosis

B Wang, K Yao, BM Huuskes, HH Shen, J Zhuang… - Molecular therapy, 2016 - cell.com
The advancement of microRNA (miRNA) therapies has been hampered by difficulties in
delivering miRNA to the injured kidney in a robust and sustainable manner. Using …

Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro

Y Zhou, H Xu, W Xu, B Wang, H Wu, Y Tao… - Stem cell research & …, 2013 - Springer
Introduction Administration of bone marrow mesenchymal stem cells (MSCs) or secreted
microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles …

[HTML][HTML] Exosomes/microvesicles as a mechanism of cell-to-cell communication

G Camussi, MC Deregibus, S Bruno, V Cantaluppi… - Kidney international, 2010 - Elsevier
Microvesicles (MVs) are circular fragments of membrane released from the endosomal
compartment as exosomes or shed from the surface membranes of most cell types. An …

Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia–reperfusion-induced acute and chronic kidney injury

S Gatti, S Bruno, MC Deregibus, A Sordi… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. Several studies demonstrated that mesenchymal stem cells (MSCs) reverse
acute kidney injury (AKI) by a paracrine mechanism rather than by MSC transdifferentiation …

Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury

S Bruno, C Grange, F Collino, MC Deregibus… - PloS one, 2012 - journals.plos.org
Several studies demonstrated that treatment with mesenchymal stem cells (MSCs) reduces
cisplatin mortality in mice. Microvesicles (MVs) released from MSCs were previously shown …

Mesenchymal stem cell-derived microvesicles protect against acute tubular injury

S Bruno, C Grange, MC Deregibus… - Journal of the …, 2009 - journals.lww.com
Administration of mesenchymal stem cells (MSCs) improves the recovery from acute kidney
injury (AKI). The mechanism may involve paracrine factors promoting proliferation of …