The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

Cell-cell communication through evolutionarily conserved signaling pathways governs
embryonic development and adult tissue homeostasis. Deregulation of these signaling …

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during
embryonic development and adult tissue homeostasis. Here we review the current …

Neuronal subtype specification in the vertebrate neural tube is one of the best-studied
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …

The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation,
with normal roles in embryonic pattern formation and adult tissue homeostasis and …

Abstract Signalling by secreted Hedgehog (Hh) proteins is important for the development of
many tissues and organs. Damage to components of the Hh signal-transduction pathway …

Intraflagellar transport (IFT) is an active event in which cargo is transported along
microtubules by motor proteins such as kinesin and dynein. IFT proteins are required for the …