Diabetes mellitus (DM), is the most common metabolic disease and is characterized by
sustained hyperglycemia. Accumulating evidences supports a strong association between …

Hepatocellular carcinoma (HCC), commonly caused by liver fibrosis, is a global challenge
with high morbidity. Activation of hepatic stellate cells (HSCs) contributes to hepatic fibrosis …

Abstract Background Cancer stem cells (CSCs) induce therapeutic resistance and may be
an important barrier to cancer immunotherapy. Chimeric antigen receptor T (CAR-T) cell …

One of the major challenges for lung cancer gene therapy is to find a gene delivery vector
with high efficiency and low toxicity. In this study, low-molecular-weight polyethyleneimine …

Simple Summary Interleukin 24 is a pleiotropic immunomodulatory cytokine. Numerous
studies have shown that enhancing or inhibiting the expression of Interleukin 24 has a …

GLI1, a key transcription factor of the Hedgehog (Hh) signaling pathway, plays an important
role in the development of cancer. However, the function and mechanisms by which GLI1 …

Breast cancer (BC) is a common malignant tumor in females around the world. While
multimodality therapies exist, the mortality rate remains high. The hypoxic condition was one …

Glioma-associated oncogene homolog 1 (GLI1), an oncogenic molecule in non-small cell
lung cancer (NSCLC), promotes the growth of NSCLC by enhancing lung cancer stem cells …

Tumor cells endure continuous DNA replication stress, which opens the way to cancer
development. Despite previous research, the prognostic implications of DNA replication …

Radiotherapy and chemotherapy are the standard care for patients with nasopharyngeal
carcinoma (NPC). These treatments cause some severe toxicity and about 30% of patients …