Bioinorganic Chemistry of Micronutrients Related to Alzheimer's and Parkinson's Diseases

A Kola, F Nencioni, D Valensin - Molecules, 2023 - mdpi.com
Metal ions are fundamental to guarantee the regular physiological activity of the human
organism. Similarly, vitamins play a key role in many biological functions of the metabolism …

Nanomedicine targets endogenous copper ions for disease diagnosis and therapy

X Li, Y Cui, T Zhou, J Li, P Lu, L Yuwen, L Wang… - Chemical Engineering …, 2023 - Elsevier
Copper ion is an essential microelement that plays vital roles in a wide range of
physiological processes, and aberrant copper levels in vivo usually cause various diseases …

A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices

DS Korde, C Humpel - Biomolecules, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by amyloid-beta (Aβ) plaques and tau neurofibrillary tangles (NFT). Modelling aspects of AD …

Alzheimer's Disease: Status of Low‐Dimensional Nanotherapeutic Materials

D Huang, W Liao, J Li, T Chen, X Wang… - Advanced Functional …, 2024 - Wiley Online Library
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that
constitutes the third most common cause of death among elderly individuals. AD patients …

Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases

Z Yang, R Feng, H Zhao - Apoptosis, 2024 - Springer
Cuproptosis, a newly characterized form of regulated cell death driven by copper
accumulation, has emerged as a significant mechanism underlying various non-cancerous …

Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics

S Prabha, M Sajad, GM Hasan, A Islam… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) is a significant neocortical degenerative disorder characterized by
the progressive loss of neurons and secondary alterations in white matter tracts …

Targeting the molecular web of Alzheimer's disease: unveiling pathways for effective pharmacotherapy

D Jadhav, N Saraswat, N Vyawahare… - The Egyptian Journal of …, 2024 - Springer
Introduction Alzheimer's disease is a neurocognitive disorder that affects elderly people by
slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of …

Diagnosis and therapy of Alzheimer's disease: Light-driven heterogeneous redox processes

W Chen, J Li, J Guo, L Li, H Wu - Advances in Colloid and Interface Science, 2024 - Elsevier
Light-driven heterogeneous processes are promising approaches for diagnosing and
treating Alzheimer's disease (AD) by regulating its relevant biomolecules. The molecular …

Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

V Das, JH Miller, CG Alladi, N Annadurai… - Medicinal Research …, 2024 - Wiley Online Library
As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …

Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease

B Mahan, Y Hu, E Lahoud, M Nestmeyer… - Metallomics, 2024 - academic.oup.com
The Alzheimer's disease (AD) affected brain purges K with concurrently increasing serum K,
suggesting brain-blood K transferal. Here, natural stable K isotope ratios—δ41K—of human …