[HTML][HTML] Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy
V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …
[HTML][HTML] CDK4/6 inhibitors: the mechanism of action may not be as simple as once thought
ME Klein, M Kovatcheva, LE Davis, WD Tap, A Koff - Cancer cell, 2018 - cell.com
CDK4/6 inhibitors are among a new generation of therapeutics. Building upon the striking
success of the combination of CDK4/6 inhibitors and the hormone receptor antagonist …
success of the combination of CDK4/6 inhibitors and the hormone receptor antagonist …
Multiple drug resistance mechanisms in cancer
BC Baguley - Molecular biotechnology, 2010 - Springer
Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human
tumours that acquire resistance to one type of therapy are found to be resistant to several …
tumours that acquire resistance to one type of therapy are found to be resistant to several …
JAK-STAT signaling in cancer: From cytokines to non-coding genome
In the past decades, studies of the Janus kinases (JAKs) and signal transducers and
activators of transcription (STATs) signaling have uncovered highly conserved programs …
activators of transcription (STATs) signaling have uncovered highly conserved programs …
Astrocytes in the aging brain express characteristics of senescence‐associated secretory phenotype
A Salminen, J Ojala, K Kaarniranta… - European Journal of …, 2011 - Wiley Online Library
Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence …
triggers several signaling cascades that can induce a condition called cellular senescence …
[HTML][HTML] MacroH2A1 and ATM play opposing roles in paracrine senescence and the senescence-associated secretory phenotype
H Chen, PD Ruiz, WM McKimpson, L Novikov… - Molecular cell, 2015 - cell.com
Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism typified by stable
proliferative arrest, a persistent DNA damage response, and the senescence-associated …
proliferative arrest, a persistent DNA damage response, and the senescence-associated …
Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling
A Schroeder, A Herrmann, G Cherryholmes, C Kowolik… - Cancer research, 2014 - AACR
Androgen receptor (AR) signaling is important for prostate cancer progression. However,
androgen-deprivation and/or AR targeting-based therapies often lead to resistance. Here …
androgen-deprivation and/or AR targeting-based therapies often lead to resistance. Here …
[HTML][HTML] Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells
A Bertolo, M Baur, J Guerrero, T Pötzel, J Stoyanov - Scientific reports, 2019 - nature.com
Mesenchymal stromal cells (MSC) are used in cell therapies, however cellular senescence
increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes …
increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes …
Pseudo-DNA damage response in senescent cells
TV Pospelova, ZN Demidenko, EI Bukreeva… - Cell cycle, 2009 - Taylor & Francis
Cellular senescence is currently viewed as a response to DNA damage. In this report, we
showed that non-damaging agents such as sodium butyrate-induced p21 and ectopic …
showed that non-damaging agents such as sodium butyrate-induced p21 and ectopic …
The Nuclear Factor κB pathway: A link to the immune system in the radiation response
CE Hellweg - Cancer Letters, 2015 - Elsevier
Exposure to ionizing radiation modulates immune responses in a complex dose-dependent
pattern, with possible anti-inflammatory effects in the low dose range, expression of pro …
pattern, with possible anti-inflammatory effects in the low dose range, expression of pro …