Regenerative medicine is extensively interested in developing cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

CDK4/6 inhibitors are among a new generation of therapeutics. Building upon the striking
success of the combination of CDK4/6 inhibitors and the hormone receptor antagonist …

Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human
tumours that acquire resistance to one type of therapy are found to be resistant to several …

In the past decades, studies of the Janus kinases (JAKs) and signal transducers and
activators of transcription (STATs) signaling have uncovered highly conserved programs …

Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence …

Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism typified by stable
proliferative arrest, a persistent DNA damage response, and the senescence-associated …

Androgen receptor (AR) signaling is important for prostate cancer progression. However,
androgen-deprivation and/or AR targeting-based therapies often lead to resistance. Here …

Mesenchymal stromal cells (MSC) are used in cell therapies, however cellular senescence
increases heterogeneity of cell populations and leads to uncertainty in therapies' outcomes …

Cellular senescence is currently viewed as a response to DNA damage. In this report, we
showed that non-damaging agents such as sodium butyrate-induced p21 and ectopic …

Exposure to ionizing radiation modulates immune responses in a complex dose-dependent
pattern, with possible anti-inflammatory effects in the low dose range, expression of pro …