Background Antidepressants are among the most commonly prescribed drugs worldwide.
They are often discontinued, frequently without the knowledge of the prescribing physician. It …

Besides demonstrated efficacy, selective serotonin reuptake inhibitors (SSRIs) hold other
advantages over earlier antidepressants such as greater tolerability and a wider range of …

We designed this study to perform a meta-analysis of gray matter (GM) findings in major
depressive disorder (MDD) by using the signed differential mapping (SDM) toolbox. The …

BACKGROUND: There is growing evidence that the brain gamma-aminobutyric acid (GABA)
system is involved in depression. Lowered plasma GABA levels were identified as a traitlike …

Objective Antidepressants are at best 50–55% effective. Non‐compliance and the
antidepressant discontinuation syndrome (ADS) are causally related yet poorly appreciated …

Objectives To investigate the antidepressant effects of Xiaoyaosan (XYS) in a chronic
unpredictable mild stress (CUMS) depression model. Methods The changes in behaviour …

Inappropriate discontinuation of drug treatment and noncompliance are a leading cause of
long-term morbidity during treatment of depression. Increasing evidence supports an …

The value of a prospective assessment of discontinuation-emergent symptoms proximal to
the termination of antidepressant treatment cannot be overstated. Though varying in …

Higenamine was included in the World Anti‐Doping Agency (WADA) Prohibited Substances
and Methods List as a β2‐adrenoceptor agonist in 2017, thereby resulting in its prohibition …

The antidepressant fluoxetine stimulates astrocytic glycogenolysis, which serves as an
energy source for axons. In multiple sclerosis patients fluoxetine administration may improve …