Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity
are strongly associated with comorbidities such as hypertension and insulin resistance …

Obesity is a worldwide pandemic contributing to the hypertensive state and to the
cardiovascular morbidity leading to an increase in hospitalizations, events and cost to the …

Insulin resistance, type 2 diabetes mellitus and associated hyperinsulinaemia can promote
the development of a specific form of cardiomyopathy that is independent of coronary artery …

Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …

Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

Chronic kidney disease (CKD) represents a global health concern, and its prevalence is
increasing. The ultimate therapeutic option for CKD is kidney transplantation. However, the …

Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation
and heart failure with preserved ejection fraction. The impairments in diastolic relaxation are …

Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly
refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults …