Integration site selection by retroviruses and transposable elements in eukaryotes

T Sultana, A Zamborlini, G Cristofari… - Nature Reviews …, 2017 - nature.com
Transposable elements and retroviruses are found in most genomes, can be pathogenic
and are widely used as gene-delivery and functional genomics tools. Exploring whether …

Accelerating Diverse Cell-Based Therapies Through Scalable Design

EL Peterman, D Ploessl… - Annual Review of …, 2024 - annualreviews.org
Augmenting cells with novel, genetically encoded functions will support therapies that
expand beyond natural capacity for immune surveillance and tissue regeneration. However …

Transmicron: accurate prediction of insertion probabilities improves detection of cancer driver genes from transposon mutagenesis screens

C Bredthauer, A Fischer, AJ Ahari, X Cao… - Nucleic Acids …, 2023 - academic.oup.com
Transposon screens are powerful in vivo assays used to identify loci driving carcinogenesis.
These loci are identified as Common Insertion Sites (CISs), ie regions with more transposon …

Prolonged activity of the transposase helper may raise safety concerns during DNA transposon-based gene therapy

G Imre, B Takács, E Czipa, AB Drubi, G Jaksa… - … Therapy Methods & …, 2023 - cell.com
DNA transposon-based gene delivery vectors represent a promising new branch of
randomly integrating vector development for gene therapy. For the side-by-side evaluation …

[HTML][HTML] Роль транспозонов в структурной эволюции геномов эукариот

РН Мустафин - Гены и клетки, 2021 - cyberleninka.ru
В обзорной статье приведены работы, доказывающие происхождение центромерных
повторов от транспозонов у растений и животных. Мобильные элементы сохраняются …

The role of transposons in the structural evolution of eukaryotic genomes

RN Mustafin - Genes & Cells, 2021 - genescells.ru
We presented evidence of the role of transposons in the occurrence of centromeric repeats
in plants and animals. During evolution, transposable elements are retained as part of …

[HTML][HTML] TRIP through the chromatin: a high throughput exploration of enhancer regulatory landscapes

AV Pindyurin, J de Jong, W Akhtar - Genomics, 2015 - Elsevier
Enhancers are regulatory elements that promote gene expression in a spatio-temporal way
and are involved in a wide range of developmental and disease processes. Both the …