New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Mining and unearthing hidden biosynthetic potential

K Scherlach, C Hertweck - Nature Communications, 2021 - nature.com
Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

antiSMASH 6.0: improving cluster detection and comparison capabilities

K Blin, S Shaw, AM Kloosterman… - Nucleic acids …, 2021 - academic.oup.com
Many microorganisms produce natural products that form the basis of antimicrobials,
antivirals, and other drugs. Genome mining is routinely used to complement screening …

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes

A Gavriilidou, SA Kautsar, N Zaburannyi, D Krug… - Nature …, 2022 - nature.com
Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

MIBiG 2.0: a repository for biosynthetic gene clusters of known function

SA Kautsar, K Blin, S Shaw… - Nucleic acids …, 2020 - academic.oup.com
Fueled by the explosion of (meta) genomic data, genome mining of specialized metabolites
has become a major technology for drug discovery and studying microbiome ecology. In …

Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

VJ Carrión, J Perez-Jaramillo, V Cordovez, V Tracanna… - Science, 2019 - science.org
Microorganisms living inside plants can promote plant growth and health, but their genomic
and functional diversity remain largely elusive. Here, metagenomics and network inference …

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences

MA Skinnider, CW Johnston… - Nature …, 2020 - nature.com
Novel antibiotics are urgently needed to address the looming global crisis of antibiotic
resistance. Historically, the primary source of clinically used antibiotics has been microbial …

Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …