X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …

X-chromosome inactivation (XCI) balances gene expression between the sexes in female
mammals. Shortly after fertilization, upregulation of Xist RNA from one X chromosome …

Conserved protein kinases with core cellular functions have been frequently redeployed
during metazoan evolution to regulate specialized developmental processes. The Ser/Arg …

Developmental genes such as Xist, which initiates X chromosome inactivation, are
controlled by complex cis-regulatory landscapes, which decode multiple signals to establish …

In female mice, the gene dosage from X chromosomes is adjusted by a process called X
chromosome inactivation (XCI) that occurs in two steps. An imprinted form of XCI (iXCI) that …

Highlights•Complex regulatory interactions ensure female-specific monoallelic Xist
expression.•Stochastic upregulation combined with a negative feedback can explain the Xist …

Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

To ensure dosage compensation between the sexes, one randomly chosen X chromosome
is silenced in each female cell in the process of X-chromosome inactivation (XCI). XCI is …

Background Precise gene dosage of the X chromosomes is critical for normal development
and cellular function. In mice, XX female somatic cells show transcriptional X chromosome …