Conspectus Native mass spectrometry is nowadays widely used for determining the mass of
intact proteins and their noncovalent biomolecular assemblies. While this technology …

Orbitrap-based charge detection mass spectrometry utilizes single-molecule sensitivity to
enable mass analysis of even highly heterogeneous, high-mass macromolecular …

Adeno-associated viruses (AAVs) are useful vehicles for gene therapy because of their
stability, low immunogenicity. and non-pathogenicity. However, disparity in AAV sample …

Highlights•The characterization of adeno-associated virus (AAV)-based gene therapy
products represents significant analytical challenges.•Recent advances in mass …

Charge-detection mass spectrometry (CDMS) enables direct measurement of the charge of
an ion alongside its mass-to-charge ratio. CDMS offers unique capabilities for the analysis of …

Adeno-associated viral (AAV) vectors have emerged as gene therapy and vaccine delivery
systems. Differential scanning fluorimetry or differential scanning calorimetry is commonly …

Immunoglobulins M (IgM) are key natural antibodies produced initially in humoral immune
response. Due to their large molecular weights and extensive glycosylation loads, IgMs …

Adeno-associated viruses (AAVs) are non-enveloped ssDNA icosahedral T= 1 viruses used
as vectors for clinical gene delivery. Currently, there are over 200 AAV-related clinical trials …

Instrumental resolution of Fourier transform-charge detection mass spectrometry instruments
with electrostatic ion trap detection of individual ions depends on the precision with which …

Adeno-associated virus (AAV) gene therapy vectors, which contain a DNA transgene
packaged into a protein capsid, have shown tremendous therapeutic potential in recent …