Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

The previous decade has seen a rapid increase in microglial studies on pain, with a unique
focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous …

Inflammation is the body's response to injury and infection, involving a complex biological
response of the somatosensory, immune, autonomic, and vascular systems. Inflammatory …

Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the
migraine attacks are sporadic; however, some individuals experience a gradual increase in …

Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …