Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?
In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …
Stress‐induced evolutionary innovation: a mechanism for the origin of cell types
Understanding the evolutionary role of environmentally induced phenotypic variation (ie,
plasticity) is an important issue in developmental evolution. A major physiological response …
plasticity) is an important issue in developmental evolution. A major physiological response …
Progesterone receptor ligands for the treatment of endometriosis: the mechanisms behind therapeutic success and failure
FM Reis, LM Coutinho, S Vannuccini… - Human …, 2020 - academic.oup.com
BACKGROUND Despite intense research, it remains intriguing why hormonal therapies in
general and progestins in particular sometimes fail in endometriosis. OBJECTIVE AND …
general and progestins in particular sometimes fail in endometriosis. OBJECTIVE AND …
Gut microbiota–derived short-chain fatty acids protect against the progression of endometriosis
Worldwide,∼ 196 million are afflicted with endometriosis, a painful disease in which
endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories on …
endometrial tissue implants and proliferates on abdominal peritoneal surfaces. Theories on …
Self-renewing endometrial epithelial organoids of the human uterus
The human endometrium is essential in providing the site for implantation and maintaining
the growth and survival of the conceptus. An unreceptive endometrium and disrupted …
the growth and survival of the conceptus. An unreceptive endometrium and disrupted …
Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota
SB Chadchan, M Cheng, LA Parnell, Y Yin… - Human …, 2019 - academic.oup.com
STUDY QUESTION Does altering gut microbiota with antibiotic treatment have any impact
on endometriosis progression? SUMMARY ANSWER Antibiotic therapy reduces …
on endometriosis progression? SUMMARY ANSWER Antibiotic therapy reduces …
The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization
Abstract The coronavirus disease 2019 (COVID-19) first appeared in December 2019 and
rapidly spread throughout the world. The SARS-CoV-2 virus enters the host cells by binding …
rapidly spread throughout the world. The SARS-CoV-2 virus enters the host cells by binding …
The mammalian decidual cell evolved from a cellular stress response
Among animal species, cell types vary greatly in terms of number and kind. The number of
cell types found within an organism differs considerably between species, and cell type …
cell types found within an organism differs considerably between species, and cell type …
A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis
Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are
governed by their cognate receptor's transcriptional output. However, the feed-forward …
governed by their cognate receptor's transcriptional output. However, the feed-forward …