Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Mitigating osteonecrosis of the jaw (ONJ) through preventive dental care and understanding of risk factors

JT Wan, DM Sheeley, MJ Somerman, JS Lee - Bone research, 2020 - nature.com
It is well established that alterations in phosphate metabolism have a profound effect on
hard and soft tissues of the oral cavity. The present-day clinical form of osteonecrosis of the …

Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use

FH Ebetino, S Sun, P Cherian, S Roshandel… - Bone, 2022 - Elsevier
Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

A natural polyphenol-functionalized chitosan/gelatin sponge for accelerating hemostasis and infected wound healing

Y Sun, T Miao, Y Wang, X Wang, J Lin, N Zhao… - Biomaterials …, 2023 - pubs.rsc.org
Natural polymers have been particularly appealing for constructing hemostatic
materials/devices, but it is still desirable to develop new natural polymer-based biomaterials …

Medication‐related osteonecrosis of the jaw: a literature review and update

S Kuroshima, FA Al‐Omari, M Sasaki, T Sawase - Genesis, 2022 - Wiley Online Library
Since the initial description of medication‐related osteonecrosis of the jaw (MRONJ) almost
two decades ago, the potential pathophysiology and risk factors have been elaborated on in …

Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

T Soma, R Iwasaki, Y Sato, T Kobayashi, E Ito… - Scientific reports, 2022 - nature.com
Invasive dental treatment such as tooth extraction following treatment with strong anti-bone
resorptive agents, including bisphosphonates and denosumab, reportedly promotes …

Bisphosphonates in veterinary medicine: the new horizon for use

LJ Suva, A Cooper, AE Watts, FH Ebetino, J Price… - Bone, 2021 - Elsevier
Bisphosphonates (BPs) are characterized by their ability to bind strongly to bone mineral
and inhibit bone resorption. However, BPs exert a wide range of pharmacological activities …

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert …

H Okawa, T Kondo, A Hokugo, P Cherian… - Elife, 2022 - elifesciences.org
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone
lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is …

Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes

H Hadad, HR Matheus, SI Pai, FA Souza… - Archives of Oral …, 2024 - Elsevier
Objective To assess the outcomes of several rodent animal models for studying tooth
extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a …

Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

R Yan, R Jiang, L Hu, Y Deng, J Wen… - International journal of …, 2022 - nature.com
Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with
administering antiresorptive or antiangiogenic drugs. Despite significant research on …