Humans are the only natural reservoir of S. pyogenes. People of any age can be affected,
even though young children and the elderly are at higher risk; males are more frequently …

Background: Two major bacterial pathogens, Staphylococcus aureus and Streptococcus
pyogenes, are becoming increasingly antibiotic-resistant. Despite the urgency, only a few …

Group A Streptococcus (GAS) is a ubiquitous pathogen that causes a wide spectrum of
human diseases. These include mild conditions such as tonsillitis and impetigo (with over …

While genome-wide transposon mutagenesis screens have identified numerous essential
genes in the significant human pathogen Streptococcus pyogenes (group A Streptococcus …

OBJECTIVE Invasive group A streptococcus (iGAS) infections are associated with a high
rate of morbidity and mortality. CNS involvement is rare, with iGAS accounting for only 0.2 …

Background Group A Streptococcus (GAS) causes multiple clinical manifestations, including
invasive (iGAS) or even life-threatening (severe-iGAS) infections. After the drop in cases …

Background In the fall of 2022, we observed a sharp rise in pediatric Invasive Group A
Streptococcus (iGAS) hospitalizations in Colorado. We compared the epidemiology, clinical …

We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone
scaffold that has antimicrobial activities against a broad spectrum of Gram-positive …

The pro-inflammatory cytokine IL-6 regulates antimicrobial responses that are broadly
crucial in the defense against infection. Our prior work shows that IL-6 promotes the killing of …

Group A Streptococcus (GAS), or Streptococcus pyogenes, is a gram-positive bacterium that
extensively colonises within the human host. GAS is responsible for causing a range of …