Laterality, heterotaxy, and isolated congenital heart defects: The genetic basis of the segmental nature of the heart
C Putotto, F Pugnaloni, M Unolt, G Calcagni… - Genome Medicine, 2024 - Springer
To date, the role of NODAL in normal and abnormal LR asymmetry has been well
established. In a recent paper, mutations of this gene have been reported in heterotaxy but …
established. In a recent paper, mutations of this gene have been reported in heterotaxy but …
Variable Effects of Laterality Genes on Disharmony Between Different Thoraco-Abdominal Organs and Between Individual Cardiac Segments
C Putotto, P Versacci, B Marino - Pediatric Cardiology, 2024 - Springer
A significant percentage of patients with heterotaxy show disharmony between abdominal,
bronchopulmonary and atrial situs. This finding is interesting in light of the variable effects of …
bronchopulmonary and atrial situs. This finding is interesting in light of the variable effects of …