Overview of myelin, major myelin lipids, and myelin-associated proteins

A Kister, I Kister - Frontiers in Chemistry, 2023 - frontiersin.org
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

CWJ van der Weijden, E Biondetti, IW Gutmann… - Brain, 2023 - academic.oup.com
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Role of white matter in cognitive impairment among relapsing remitting multiple sclerosis patients

M Elkhooly, F Bao, M Raghib, S Millis… - Multiple Sclerosis and …, 2023 - Elsevier
Abstract Background Multiple Sclerosis (MS) associated cognitive impairment is believed to
be mostly connected with damage to gray matter. The contribution of white matter is still …

Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals

Z Gong, M Bilgel, M Kiely, C Triebswetter… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction The influence of myelination on longitudinal changes in cognitive performance
remains unclear. Methods For each participant (N= 123), longitudinal cognitive scores were …

Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review

ME Faulkner, Z Gong, A Guo, JP Laporte… - Journal of …, 2024 - Wiley Online Library
Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …

GABAB receptor agonist baclofen promotes central nervous system remyelination

MP Serrano‐Regal, L Bayón‐Cordero… - Glia, 2022 - Wiley Online Library
Promoting remyelination is considered as a potential neurorepair strategy to prevent/limit the
development of permanent neurological disability in patients with multiple sclerosis (MS). To …

Using myelin water imaging to link underlying pathology to clinical function in multiple sclerosis: A scoping review

EM Edwards, W Wu, NE Fritz - Multiple Sclerosis and Related Disorders, 2022 - Elsevier
Background Multiple sclerosis (MS) symptoms and pathology are heterogenous and
complex. Identifying links between MS-related pathology (ie, myelin damage) and …

Innate immune cells and myelin profile in multiple sclerosis: a multi-tracer PET/MR study

MS Pitombeira, M Koole, KR Campanholo… - European journal of …, 2022 - Springer
Purpose Neuropathological studies have demonstrated distinct profiles of microglia
activation and myelin injury among different multiple sclerosis (MS) phenotypes and …

Roles of osteocalcin in the central nervous system

XS Qi, X He, Y Peng, XH He, QY Yang… - CNS Neuroscience & …, 2024 - Wiley Online Library
Background Bone‐derived protein osteocalcin, which has beneficial effects on brain
function, may be a future research direction for neurological disorders. A growing body of …

Update on myelin imaging in neurological syndromes

S Balaji, P Johnson, AV Dvorak… - Current Opinion in …, 2022 - journals.lww.com
Update on myelin imaging in neurological syndromes : Current Opinion in Neurology Update
on myelin imaging in neurological syndromes : Current Opinion in Neurology Log in or …