Periostin is a secretory protein with a multi-domain structure, comprising an amino-terminal
cysteine-rich EMI domain, four internal FAS 1 domains, and a carboxyl-terminal hydrophilic …

Fibrillar proteins are principal components of extracellular matrix (ECM) that confer
mechanical properties to tissues. Fibrosis can result from wound repair in nearly every tissue …

After myocardial infarction (MI), the heart's reparative response to the ischemic insult and the
related loss of cardiomyocytes involves cardiac fibrosis, in which the damaged tissue is …

Most patients infected with SARS-CoV-2 display mild symptoms with good prognosis, while
20% of patients suffer from severe viral pneumonia and up to 5% may require intensive care …

Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized
by both innate and adaptive immune responses; however, their specific roles in the …

Although the matricellular protein periostin is prominently upregulated in skin and gingival
healing, it plays contrasting roles in myofibroblast differentiation and matrix synthesis …

Aims The temporal sequence of events underlying functional right ventricular (RV) recovery
after improvement of pulmonary hypertension-associated pressure overload is unknown. We …

Background The transition from normal lung anatomy to minimal and established fibrosis is
an important feature of the pathology of idiopathic pulmonary fibrosis (IPF). The purpose of …

Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that
causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro …

Pulmonary angiogenesis is a key driver of alveolarization. Our prior studies showed that NF-
κB promotes pulmonary angiogenesis during early alveolarization. However, the …