Animal models of Parkinson's disease: bridging the gap between disease hallmarks and research questions
A Dovonou, C Bolduc, V Soto Linan, C Gora… - Translational …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …
Detection and modulation of neurodegenerative processes using graphene-based nanomaterials: Nanoarchitectonics and applications
Neurodegenerative disorders (NDDs) are caused by progressive loss of functional neurons
following the aggregation and fibrillation of proteins in the central nervous system. The …
following the aggregation and fibrillation of proteins in the central nervous system. The …
Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease
F Muhammad, Y Liu, N Wang, L Zhao, Y Zhou, H Yang… - Neurotoxicology, 2022 - Elsevier
Parkinson disease (PD) is the second most progressive neurodegenerative disorder of the
central nervous system (CNS) in the elderly, causing motor impediments and cognitive …
central nervous system (CNS) in the elderly, causing motor impediments and cognitive …
Aggregation of alpha-synuclein disrupts mitochondrial metabolism and induce mitophagy via cardiolipin externalization
Accumulation of α-synuclein aggregates in the substantia nigra pars compacta is central in
the pathophysiology of Parkinson's disease, leading to the degeneration of dopaminergic …
the pathophysiology of Parkinson's disease, leading to the degeneration of dopaminergic …
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson's disease in rodent brains
M Bérard, L Martínez-Drudis, R Sheta… - Molecular …, 2023 - Springer
Background Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal
inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson's …
inclusions, called Lewy bodies (LBs), is the neuropathological hallmark of Parkinson's …
Update on Therapeutic potential of emerging nanoformulations of phytocompounds in Alzheimer's and Parkinson's disease
The prevalence of neurodegenerative disorders (NDs) has increased recently, with
Parkinson's disease (PD) and Alzheimer's disease (AD) being the two utmost prevalent …
Parkinson's disease (PD) and Alzheimer's disease (AD) being the two utmost prevalent …
Intracellular tau fragment droplets serve as seeds for tau fibrils
Intracellular tau aggregation requires a local protein concentration increase, referred to as
droplets. However, the cellular mechanism remains insufficiently understood. We expressed …
droplets. However, the cellular mechanism remains insufficiently understood. We expressed …
Nicotine-mediated therapy for Parkinson's disease in transgenic Caenorhabditis elegans model
Parkinson's disease resultant in the degeneration of Dopaminergic neurons and
accumulation of α-synuclein in the substantia nigra pars compacta. The synthetic …
accumulation of α-synuclein in the substantia nigra pars compacta. The synthetic …
[HTML][HTML] Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons
Generation of functional human dopaminergic (DA) neurons from human induced
pluripotent stem cells (hiPSCs) is a crucial tool for modeling dopamine-related human …
pluripotent stem cells (hiPSCs) is a crucial tool for modeling dopamine-related human …
C9orf72 poly-PR forms anisotropic condensates causative of nuclear TDP-43 pathology
RE Hodgson, JA Rayment, WP Huang, AS Avila… - iScience, 2024 - cell.com
Proteinaceous inclusions formed by C9orf72-derived dipeptide-repeat (DPR) proteins are a
histopathological hallmark in∼ 50% of familial amyotrophic lateral sclerosis/frontotemporal …
histopathological hallmark in∼ 50% of familial amyotrophic lateral sclerosis/frontotemporal …