[HTML][HTML] Image-based predictive modelling frameworks for personalised drug delivery in cancer therapy
Personalised drug delivery enables a tailored treatment plan for each patient compared to
conventional drug delivery, where a generic strategy is commonly employed. It can not only …
conventional drug delivery, where a generic strategy is commonly employed. It can not only …
A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy
M Steuperaert, C Debbaut, C Carlier, O De Wever… - Drug …, 2019 - Taylor & Francis
Although intraperitoneal chemotherapy (IPC) has evolved into an established treatment
modality for patients with peritoneal metastasis (PM), drug penetration into tumor nodules …
modality for patients with peritoneal metastasis (PM), drug penetration into tumor nodules …
Heterogeneous mechanical stress and interstitial fluid flow predictions derived from DCE-MRI for Rat U251N orthotopic gliomas
JA Rey, KG Spanick, G Cabral… - Annals of biomedical …, 2024 - Springer
Mechanical stress and fluid flow influence glioma cell phenotype in vitro, but measuring
these quantities in vivo continues to be challenging. The purpose of this study was to predict …
these quantities in vivo continues to be challenging. The purpose of this study was to predict …
Perfusion kinetics in human brain tumor with DCE-MRI derived model and CFD analysis
Cancer is one of the leading causes of death all over the world. Among the strategies that
are used for cancer treatment, the effectiveness of chemotherapy is often hindered by factors …
are used for cancer treatment, the effectiveness of chemotherapy is often hindered by factors …
Convection-enhanced delivery of antiangiogenic drugs and liposomal cytotoxic drugs to heterogeneous brain tumor for combination therapy
Simple Summary Although developed anticancer drugs have shown desirable effects in
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …
preclinical trials, the clinical efficacy of chemotherapy against brain cancer remains …
Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network
Purpose Proof‐of‐concept study of mapping renal blood flow vector field according to the
inverse solution to a mass transport model of time resolved tracer‐labeled MRI data. Theory …
inverse solution to a mass transport model of time resolved tracer‐labeled MRI data. Theory …
Computational modeling of interstitial fluid pressure and velocity in head and neck cancer based on dynamic contrast-enhanced magnetic resonance imaging …
E LoCastro, R Paudyal, Y Mazaheri, V Hatzoglou… - …, 2020 - pmc.ncbi.nlm.nih.gov
We developed and tested the feasibility of computational fluid modeling (CFM) based on
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for quantitative …
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for quantitative …
Radiopharmaceutical transport in solid tumors via a 3-dimensional image-based spatiotemporal model
Lutetium-177 prostate-specific membrane antigen (177Lu-PSMA)-targeted
radiopharmaceutical therapy is a clinically approved treatment for patients with metastatic …
radiopharmaceutical therapy is a clinically approved treatment for patients with metastatic …
A computational model of glioma reveals opposing, stiffness-sensitive effects of leaky vasculature and tumor growth on tissue mechanical stress and porosity
A biphasic computational model of a growing, vascularized glioma within brain tissue was
developed to account for unique features of gliomas, including soft surrounding brain tissue …
developed to account for unique features of gliomas, including soft surrounding brain tissue …
MRI-based computational model of heterogeneous tracer transport following local infusion into a mouse hind limb tumor
KN Magdoom, GL Pishko, L Rice, C Pampo… - PloS one, 2014 - journals.plos.org
Systemic drug delivery to solid tumors involving macromolecular therapeutic agents is
challenging for many reasons. Amongst them is their chaotic microvasculature which often …
challenging for many reasons. Amongst them is their chaotic microvasculature which often …