Aberrant accumulation of misfolded proteins into amyloid deposits is a hallmark in many age-
related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's …

Prions are unusual proteinaceous infectious agents that are typically associated with a class
of fatal degenerative diseases of the mammalian brain. However, the discovery of fungal …

It is increasingly recognized that molecular chaperones play a key role in modulating the
formation of amyloid fibrils, a process associated with a wide range of human disorders …

Background Diverse organisms across taxa are desiccation tolerant, capable of surviving
extreme water loss. Remarkably, desiccation tolerant organisms can survive years without …

Evolution depends on the manner in which genetic variation is translated into new
phenotypes. There has been much debate about whether organisms might have specific …

Hsp70 chaperones interact with a wide spectrum of substrates ranging from unfolded to
natively folded and aggregated proteins. Structural evidence suggests that bound substrates …

The accumulation and prion‐like propagation of α‐synuclein and other amyloidogenic
proteins are associated with devastating neurodegenerative diseases. Metazoan heat shock …

Several well-characterized fungal proteins act as prions, proteins capable of multiple
conformations, each with different activities, at least one of which is self-propagating …

Yeast prions, such as [PSI+],[RNQ+], and [URE3], are heritable elements formed by proteins
capable of acquiring self-perpetuating conformations. Their propagation is dependent on …

Prions in Saccharomyces cerevisiae are inherited ordered aggregates reliant upon the
disaggregase Hsp104 for stable maintenance. The function of other factors in the natural …