Nasopharyngeal carcinoma: an evolving paradigm

KCW Wong, EP Hui, KW Lo, WKJ Lam… - Nature reviews Clinical …, 2021 - nature.com
The past three decades have borne witness to many advances in the understanding of the
molecular biology and treatment of nasopharyngeal carcinoma (NPC), an Epstein–Barr virus …

Nasopharyngeal carcinoma

YP Chen, ATC Chan, QT Le, P Blanchard, Y Sun, J Ma - The Lancet, 2019 - thelancet.com
Nasopharyngeal carcinoma is characterised by distinct geographical distribution and is
particularly prevalent in east and southeast Asia. Epidemiological trends in the past decade …

Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

HQ Mai, QY Chen, D Chen, C Hu, K Yang, J Wen, J Li… - Nature medicine, 2021 - nature.com
Gemcitabine-cisplatin (GP) chemotherapy is the standard first-line systemic treatment for
recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). In this international, double …

The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

LL Tang, YP Chen, CB Chen, MY Chen… - Cancer …, 2021 - Wiley Online Library
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor originating in the
nasopharynx and has a high incidence in Southeast Asia and North Africa. To develop these …

[HTML][HTML] Efficacy, safety, and correlative biomarkers of toripalimab in previously treated recurrent or metastatic nasopharyngeal carcinoma: a phase II clinical trial …

FH Wang, XL Wei, J Feng, Q Li, N Xu… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
PURPOSE As yet, no checkpoint inhibitor has been approved to treat nasopharyngeal
carcinoma (NPC). This study was aimed to evaluate the antitumor activity, safety, and …

[HTML][HTML] Gemcitabine and cisplatin induction chemotherapy in nasopharyngeal carcinoma

Y Zhang, L Chen, GQ Hu, N Zhang… - … England Journal of …, 2019 - Mass Medical Soc
Background Platinum-based concurrent chemoradiotherapy is the standard of care for
patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine …

Camrelizumab (SHR-1210) alone or in combination with gemcitabine plus cisplatin for nasopharyngeal carcinoma: results from two single-arm, phase 1 trials

W Fang, Y Yang, Y Ma, S Hong, L Lin, X He… - The Lancet …, 2018 - thelancet.com
Background Platinum-based doublet chemotherapy regimens, preferentially gemcitabine
plus cisplatin, are generally considered the first-line standard of care for patients with …

NCCN guidelines insights: head and neck cancers, version 1.2018

AD Colevas, SS Yom, DG Pfister, S Spencer… - Journal of the National …, 2018 - jnccn.org
The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment
recommendations for cancers of the lip, oral cavity, pharynx, larynx, ethmoid and maxillary …

[PDF][PDF] Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309)

Y Yang, J Pan, H Wang, Y Zhao, S Qu, N Chen, X Chen… - Cancer Cell, 2023 - cell.com
Checkpoint inhibitors are effective in recurrent/metastatic nasopharyngeal cancer (R/M
NPC). RATIONALE-309 (NCT03924986) randomized 263 treatment-naive R/M NPC …

Radiomics features of multiparametric MRI as novel prognostic factors in advanced nasopharyngeal carcinoma

B Zhang, J Tian, D Dong, D Gu, Y Dong, L Zhang… - Clinical Cancer …, 2017 - AACR
Purpose: To identify MRI-based radiomics as prognostic factors in patients with advanced
nasopharyngeal carcinoma (NPC). Experimental Design: One-hundred and eighteen …