Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer …
Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer
J Zeng, W Fan, J Li, G Wu, H Wu - International Journal of General …, 2023 - Taylor & Francis
Background The occurrence, progression, and prognosis of colorectal cancer (CRC) are
regulated by EGFR-mediated signaling pathways. However, the relationship between the …
regulated by EGFR-mediated signaling pathways. However, the relationship between the …
[HTML][HTML] Evaluation of ctDNA in the prediction of response to Neoadjuvant Therapy and Prognosis in locally advanced rectal Cancer patients: a prospective study
M Morais, T Fonseca, D Melo-Pinto, I Prieto, AT Vilares… - Pharmaceuticals, 2023 - mdpi.com
“Watch and wait” is becoming a common treatment option for patients with locally advanced
rectal cancer (LARC) submitted to neoadjuvant treatment. However, currently, no clinical …
rectal cancer (LARC) submitted to neoadjuvant treatment. However, currently, no clinical …
[HTML][HTML] The efficacy-associated biomarkers for immune checkpoint inhibitors in gastrointestinal cancer: a literature review
P Zhao, R Jin, B Zhao, L Han, W Chen… - Journal of …, 2024 - ncbi.nlm.nih.gov
The efficacy-associated biomarkers for immune checkpoint inhibitors in gastrointestinal cancer:
a literature review - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …
a literature review - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …
[HTML][HTML] The cost-effectiveness analysis of serplulimab versus regorafenib for treating previously treated unresectable or metastatic microsatellite instability-high or …
Y Ma, J Zhou, Y Ye, X Wang, A Ma, H Li - Frontiers in Oncology, 2023 - frontiersin.org
Objective The aim of this study was to investigate the cost-effectiveness of serplulimab
versus regorafenib in previously treated unresectable or metastatic microsatellite instability …
versus regorafenib in previously treated unresectable or metastatic microsatellite instability …
[HTML][HTML] Neoadjuvant Chemoradiation for Rectal Cancer Achieves Satisfactory Tumour Regression and Local Recurrence–Result of a Dedicated Multi-disciplinary …
R Deen, DS Ediriweera, S Thillakaratne… - BMC cancer, 2023 - Springer
Background Pre-operative long-course chemoradiotherapy (CRT) for rectal cancer has
resulted in improvement in rates of restorative rectal resection and local recurrence by …
resulted in improvement in rates of restorative rectal resection and local recurrence by …
[HTML][HTML] HNRNPA2B1-mediated MicroRNA-92a upregulation and section acts as a promising noninvasive diagnostic biomarker in colorectal cancer
Y Li, K Li, X Lou, Y Wu, S Seery, D Xu, Y Pei, B Qian… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the second leading cause of cancer deaths,
with approximately 15–25% of the primary diagnosis. MicroRNA-92a (miR-92a) is …
with approximately 15–25% of the primary diagnosis. MicroRNA-92a (miR-92a) is …
Seed and Soil: Consensus Molecular Subgroups (CMS) and Tumor Microenvironment Features Between Primary Lesions and Metastases of Different Organ Sites in …
Q Luo, Y Quan, W Liu, Z Wu, W Qiu… - Cancer Management …, 2024 - Taylor & Francis
Purpose Consensus molecular subtypes (CMS) are mainly used for biological
interpretability and clinical stratification of colorectal cancer (CRC) in primary tumors (PT) but …
interpretability and clinical stratification of colorectal cancer (CRC) in primary tumors (PT) but …
Revolutionizing prognostic predictions in colorectal cancer: Macrophage‑driven transcriptional insights from single‑cell RNA sequencing and gene co‑expression …
Y Feng, Z Cheng, J Gao, T Huang… - Oncology …, 2024 - spandidos-publications.com
Tumor‑associated macrophages have become important biomarkers for cancer diagnosis,
prognosis and therapy. The dynamic changes in macrophage subpopulations significantly …
prognosis and therapy. The dynamic changes in macrophage subpopulations significantly …
Bioinformatics analysis and identification of cuproptosis-related long non-coding RNAs in colorectal cancer
W Chen, D Huang, X Su, Y Su… - Journal of International …, 2024 - journals.sagepub.com
Objective Identifying precise biomarkers for colorectal cancer (CRC) detection and
management remains challenging. Here, we developed an innovative prognostic model for …
management remains challenging. Here, we developed an innovative prognostic model for …