ABSTRACT Three-dimensional (3D) organization of the human genome plays an essential
role in all DNA-templated processes, including gene transcription, gene regulation, and …

Highlights•Coevolution of molecular interfaces induces direct correlations between sites of
interacting sequences.•Global models that identify direct correlations in sequences of …

Significant efforts have been recently made to obtain the three-dimensional (3D) structure of
the genome with the goal of understanding how structures may affect gene regulation and …

An array of motor proteins consumes chemical energy in setting up the architectures of
chromosomes. Here, we explore how the structure of ideal polymer chains is influenced by …

Mammalian genomes are intricately compacted to form sophisticated 3-dimensional
structures within the tiny nucleus, so called 3D genome folding. Despite their shapes …

The human genome is organized within a nucleus where chromosomes fold into an
ensemble of different conformations. Chromosome conformation capture techniques such as …

Assemblies of structural maintenance of chromosomes (SMC) proteins and kleisin subunits
are essential to chromosome organization and segregation across all kingdoms of life. While …

Chromatin, the complex assembly of DNA and associated proteins, plays a pivotal role in
orchestrating various genomic functions. To aid our understanding of the principles …

DNA looping plays an important role in cells in both regulating and protecting the genome.
Often, studies of looping focus on looping by prokaryotic transcription factors like lac …

DNA-binding response regulators (DBRRs) are a broad class of proteins that operate in
tandem with their partner kinase proteins to form two-component signal transduction …