Although low-grade gliomas (LGG) have a less aggressive course than do high-grade
gliomas, the outcome of these tumours is ultimately fatal in most patients. Both the tumour …

Tumor treating fields (TTFields) are low-intensity electric fields alternating at an intermediate
frequency (200kHz), which have been demonstrated to block cell division and interfere with …

Importance Tumor-treating fields (TTFields) is an antimitotic treatment modality that
interferes with glioblastoma cell division and organelle assembly by delivering low-intensity …

Background Bevacizumab is approved for the treatment of patients with progressive
glioblastoma on the basis of uncontrolled data. Data from a phase 2 trial suggested that the …

Importance Glioblastoma is the most devastating primary malignancy of the central nervous
system in adults. Most patients die within 1 to 2 years of diagnosis. Tumor-treating fields …

Background Whole brain radiotherapy (WBRT) and dexamethasone are widely used to treat
brain metastases from non-small cell lung cancer (NSCLC), although there have been no …

Background Standard therapy for newly diagnosed glioblastoma is radiotherapy plus
temozolomide. In this phase 3 study, we evaluated the effect of the addition of bevacizumab …

Purpose People with HIV are living longer as a result of effective antiretroviral therapy.
Cancer has become a leading cause of morbidity and mortality in this patient population …

Purpose This phase III trial compared adjuvant whole-brain radiotherapy (WBRT) with
observation after either surgery or radiosurgery of a limited number of brain metastases in …

Backround The number of cancer survivors is growing steadily and increasingly, clinical
trials are being designed to include long-term follow-up to assess not only survival, but also …